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| dc.contributor.author | Sampath, S.N.T.I. | |
| dc.contributor.author | Jayasinghe, S.S. | |
| dc.contributor.author | Attanayake, A.P. | |
| dc.contributor.author | Karunaratne, V. | |
| dc.contributor.author | Yaddehige, M.L. | |
| dc.date.accessioned | 2023-09-18T11:55:10Z | |
| dc.date.available | 2023-09-18T11:55:10Z | |
| dc.date.issued | 2022-12 | |
| dc.identifier.citation | Sampath, S. N. T. I., Jayasinghe, S., Attanayake, A. P., Karunaratne, V., Yaddehige, M. L., & Watkins, D. L. (2022). A new dimeric carbazole alkaloid from Murraya koenigii (L.) leaves with α-amylase and α-glucosidase inhibitory activities. Phytochemistry Letters, 52, 87-91. | en_US |
| dc.identifier.uri | http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/14728 | |
| dc.description.abstract | A new dimeric carbazole alkaloid, 3,3′,5,5′,8-pentamethyl-3,3′-bis(4-methylpent-3-en-1-yl)-3,3′,11,11′-tetrahydro-10,10′-bipyrano[3,2-a]carbazole, was isolated from the hexane extract of leaves of Murraya koenigii (L.) Sprengel. (Family: Rutaceae). The structure was elucidated based on 13C and 1H NMR, High-Resolution Mass Spectrometry (HRMS), and 2D NMR data. The in vitro antidiabetic activity of the new dimer was investigated in terms of α-amylase and α-glucosidase enzyme inhibition assays. The dimer exhibited significant α-amylase inhibitory activity (IC50 = 30.32 ± 0.34 ppm) and α-glucosidase inhibitory activity (IC50 = 30.91 ± 0.36 ppm). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Murraya koenigii | en_US |
| dc.subject | α-Glucosidase | en_US |
| dc.subject | new dimeric carbazole alkaloid | en_US |
| dc.subject | α-Amylase | en_US |
| dc.subject | percent inhibitory activity | en_US |
| dc.title | A New Dimeric Carbazole Alkaloid from Murraya Koenigii (L.) Leaves with α-amylase and α-glucosidase Inhibitory Activities | en_US |
| dc.type | Article | en_US |
