Inflammatory Status and Vitamin D Concentration Among Patients with end Stage Renal Failure: a Hospital Based Comparative Study

Abstract

Background Vitamin D (25(OH)D) deficiency is common among patients with chronic kidney disease. Vitamin D deficiency at the initiation of dialysis correlates with the risk of premature death. Vitamin D is one of the key controllers of systemic inflammation. Studies have also shown that Vitamin D deficiency is linked with inflammatory diseases. Objective Objectives of this study were to assess the inflammatory status and Vitamin D levels among patients with end stage renal failure (ESRF) and compare with age and sex-matched controls. Method A group of 38 (Men=30) patients with end stage renal failure attending Teaching Hospitals, Karapitiya and Kandy and age and sex-matched community controls were recruited for the study after informed written consent. A sample of blood was collected to estimate serum concentration of high sensitivity C-reactive protein (hs-CRP) and 25(OH)D. Data were analysed using descriptive statistics, two sample-t test and Mann-whitney test. Results Mean (+SD) age of the patients and controls were 45(+10) years and 44(+10) years respectively. Mean hs-CRP concentration of ESRF patients was significantly higher compared to controls (4.9 vs 1.78mg/L, p=0.009). Median 25(OH)D concentration of patients (17.97 ng/mL) was significantly lower compared to controls (30.5 ng/mL) (p=0.0096). There were 12 patients with vitamin D deficiency (<10ng/mL) and 14 patients with insufficiency (10-29ng/mL) among patients with ESRF. Conclusion Patients with ESRF have high hs-CRP and low vitamin D concentrations and these may contribute to the multiple clinical outcomes of patients with ESRF.