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Scholarly Publications: Recent submissions

  • An Under-recognized Influenza Epidemic Identified by Rapid Influenza Testing, Southern Sri Lanka, 2013 
    Tillekeratne, L.G.; Bodinayake, C.K.; Nagahawatte, A.; Vidanagama, D.; Arachchi, W.K.; Kurukulasooriya, R.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W. (The American journal of tropical medicine and hygiene, 2015-05-02)
    Influenza accounts for a large burden of acute respiratory tract infections in high-income countries; data from lower-income settings are limited due to lack of confirmatory testing. Consecutive outpatients presenting to ...
  • Use of Rapid Influenza Testing to Reduce Antibiotic Prescriptions Among Outpatients with Influenza-Like Illness in Southern Sri Lanka 
    Tillekeratne, L.G.; Bodinayake, C.K.; Nagahawatte, A.; Vidanagama, D.; Anderson, W.K.; Kurukulasooriya, R.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W. (The American journal of tropical medicine and hygiene, 2015-11)
    Acute respiratory tract infections (ARTIs) are a common reason for unnecessary antibiotic prescriptions worldwide. Our objective was to determine if providing access to rapid influenza test results could reduce antibiotic ...
  • Dengue Fever Associated with Extreme Reactive Thrombocytosis 
    Egodage, U.K.; Dissanayake, N.U.; Dahanayake, M.U.; Bodinayake, C.K. (The Sri Lanka Medical Association, 2016-12-30)
    Dengue is an important viral illness which has the potential to progress into dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Leucopenia and throm-bocytopenia are the hallmarks of acute dengue which ...
  • Extended-spectrum ß-Lactamase-producing Enterobacteriaceae as a Common Cause of Urinary Tract Infections in Sri Lanka 
    Tillekeratne, L.G.; Vidanagama, D.; Tippalagama, R.; Lewkebandara, R.; Joyce, Maria; Nicholson, B.P.; Nagahawatte, A.; Bodinayake, C.K.; De Silva, A.D.; Woods, Christopher W. (Infect Chemother, 2016-09-23)
    Background: Extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) are increasingly reported as pathogens in urinary tract infections (UTIs). However, in Sri Lanka, the clinical and molecular epidemiology ...
  • Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka 
    Bodinayake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Sessions, October M.; Kurukulasooriya, R.; Uehara, Anna; Howe, Shiqin; Xin Mei Ong; Tan, Sharon; Chow, Angelia; Tummalapalli, P.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Gubler, Duane J.; Reller, Megan E. (Public Library of Science (PLOS), 2016-10-06)
    Background Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily along the heavily urbanized western coast with ...
  • Challenges of Managing Enterobacter Endocarditis; a Review of Two Cases 
    Piyasiri, D.L.B.; Priyarangani, W.K.A.P.; Kariyawasam, I.; Wijeweera, D.; Bodinayake, C.K.; Kodikaraarachchi, R.W.K.; Madurawe, D.R.; Sathananthan, P.P.; Jayasekara, J.V.G.M. (Galle Medical Association, 2017-03-28)
    Introduction Infective endocarditis (IE) carries significant mortality and morbidity and Streptococci and Staphylococci are the common causative organisms Apart from the HACEK group (Haemophilus, Actinobacillus, ...
  • Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka 
    Shapiro, David; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Hsiang, Jeremy; Nicholson, B.P.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W.; Tillekeratne, L.G. (The American journal of tropical medicine and hygiene, 2017-07-12)
    In tropical and subtropical settings, the epidemiology of viral acute respiratory tract infections varies widely between countries. We determined the etiology, seasonality, and clinical presentation of viral acute respiratory ...
  • Antibiotic Overuse for Acute Respiratory Tract Infections in Sri Lanka: a Qualitative Study of Outpatients and their Physicians 
    Tillekeratne, L.G.; Bodinayake, C.K.; Dabrera, T.; Nagahawatte, A.; Arachchi, W.K.; Sooriyaarachchi, A.; Stewart, Kearsley; Watt, Melissa; Ostbye, T.; Woods, Christopher W. (BioMed Central Ltd., 2017-03-16)
    Background: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka with ...
  • Severe Anaemia and Multiple Ecchymoses in a Postpartum Female Due to Acquired Haemophilia A 
    Palangasinghe, D.R.; Gamage, V.N.U.; Bodinayake, C.K.; Mohotti, M.G.M. (Galle Medical Association, 2017-03-28)
    Acquired haemophilia A (AHA) is a rare acquired bleeding disorder with a worldwide incidence of 2 per million of the population (1). It has a bimodal age distribution including postpartum period and adults over 50 years ...
  • Analysis of Dengue Serotype 4 in Sri Lanka During the 2012–2013 Dengue Epidemic 
    Uehara, Anna; Tissera, H.A.; Bodinayake, C.K.; Amarasinghe, A.; Nagahawatte, A.; Tillekeratne, L.G.; Jie Cui; Reller, Megan E.; Palihawadana, P.; Gunasena, S.; De Silva, A.D.; Wilder-Smith, A.; Gubler, Duane J.; Woods, Christopher W.; Sessions, October M. (The American journal of tropical medicine and hygiene, 2017-07-12)
    The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks ...
  • An Unusual Cause for Periodic Limb Paralysis; Gitelman Syndrome 
    Jayasekara, J.M.S.; Palangasinghe, D.R.; Bodinayake, C.K. (Galle Medical Association, 2018-03-30)
    Gitelman syndrome (GS) is an autosomal recessively inherited salt loosing tubulopathy with a prevalence of 1-10 per 40,000 people (1, 2). The prevalence of GS is higher in Asia than other countries (2). GS is characterized ...
  • Differentiating Scrub Typhus Meningoencephalitis, from Tuberculous Meningitis: Two Case Reports and a Review 
    De Silva, C.M.; Fonseka, C.L.; Nanayakkara, S.D.; Singhapura, S.D.A.L.; Palangasinghe, D.R.; Hewawithana, J.S.; Pathirana, K.D.; Bodinayake, C.K. (Galle Medical Association, 2018-03-01)
    Scrub typhus is a zoonotic disease where currently about one million new cases are identified annually and one billion people may be at risk of this disease (1-3). The infection is acquired through agricultural activities ...
  • Methicillin-resistant Staphylococcus Aureus: Prevalence of and Risk Factors Associated with Colonization of Patients on Admission to the Teaching Hospital, Karapitiya 
    Kurukulasooriya, R.; Tillekeratne, L.G.; Wijayaratne, W.M.D.G.B.; Bodinayake, C.K.; De Silva, A.D.; Nicholson, B.P.; Ostbye, T.; Woods, Christopher W.; Nagahawatte, A. (University of Ruhuna, 2018-12-30)
    Methicillin-resistant Staphylococcus aureus (MRSA) causes a substantial burden of community-acquired and nosocomial infection. Prior colonization with MRSA is a recognized risk factor for MRSA infection. The study aimed ...
  • Evaluation of the WHO 2009 Classification for Diagnosis of Acute Dengue in a Large Cohort of Adults and Children in Sri Lanka During a Dengue-1 Epidemic 
    Bodinayake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Sessions, October M.; Kurukulasooriya, R.; Uehara, Anna; Howe, Shiqin; Xin Mei Ong; Tan, Sharon; Chow, Angelia; Tummalapalli, P.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Gubler, Duane J.; Reller, Megan E. (Public Library of Science (PLOS), 2018-02-09)
    Background Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical diagnosis of dengue. Methodology/Principal ...
  • Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka 
    Tillekeratne, L.G.; Bodinayake, C.K.; Simmons, R.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Vanderburg, Sky; Kurukulasooriya, R.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W. (The American journal of tropical medicine and hygiene, 2018-12-26)
    he contribution of respiratory viruses to acute febrile illness (AFI) burden is poorly characterized. We describe the prevalence, seasonality, and clinical features of respiratory viral infection among AFI admissions in ...
  • Point-prevalence Study of Antimicrobial Use in Public Hospitals in Southern Sri Lanka Identifies Opportunities for Improving Prescribing Practices 
    Tianchen Sheng; Wijayaratne, W.M.D.G.B.; Dabrera, T.M.; Drew, Richard J.; Nagahawatte, A.; Bodinayake, C.K.; Kurukulasooriya, R.; Ostbye, T.; Nagaro, Kristin J.; De Silva, C.; Ranawakaarachchi, H.; Sudarshana, A.T.; Anderson, Deverick J.; Weerasinghe, Christopher W.; Tillekeratne, L.G. (Cambridge University Press, 2019-02-01)
    A point-prevalence study of antimicrobial use among inpatients at 5 public hospitals in Sri Lanka revealed that 54.6% were receiving antimicrobials: 43.1% in medical wards, 68.0% in surgical wards, and 97.6% in intensive ...
  • Extrapulmonary Tuberculosis Presenting as a Dumbbell Tumour of the Chest Wall 
    Kariyawasam, A.G.T.A.; Fonseka, C.L.; Rasnayake, D.; Singhapura, S.D.A.L.; Sanjeewa, A.D.S.; Hewavithana, J.; Masakorala, N.D.; Dahanayake, N.J.; Bodinayake, C.K. (Galle Medical Association, 2019-03-01)
    Tuberculosis gives rise to a significant impact on the healthcare burden in tropical countries where it can present in a variety of ways. The commonest site of tuberculous infection is the lung, while extra-pulmonary ...
  • Use of Clinical Algorithms and Rapid Influenza Testing to Manage Influenza-like Illness: a Cost-effectiveness Analysis in Sri Lanka. 
    Tillekeratne, L.G.; Bodinayake, C.K.; Nagahawatte, A.; Kurukulasooriya, R.; Orlando, Lori A.; Simmons, Ryan A.; Park, Lawrence P.; Woods, Christopher W.; Reed, Shelby D. (BMJ Publishing Group Ltd., 2019-03-30)
    Background Acute respiratory infections are a common reason for antibiotic overuse. We previously showed that providing Sri Lankan clinicians with positive rapid influenza test results was associated with a reduction in ...
  • Geospatial Analysis of Dengue Emergence in Rural Areas in the Southern Province of Sri Lanka 
    Mutucumarana, C.P.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Anuradha, T.; De Silva, A.D.; Janko, Mark M.; Ostbye, T.; Gubler, Duane J.; Woods, Christopher W.; Reller, Megan E.; Tillekeratne, L.G.; Lantos, Paul M. (Oxford University Press, 2020-06-01)
    Background: Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012–2013, we documented that acute dengue was surprisingly associated with self- reported ...
  • Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population 
    Tillekeratne, L.G.; Suchindran, S.; Ko, Emily R.; Petzold, Elizabeth A.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Nicholson, B.P.; McClain, Micah T.; Burke, Thomas W.; Tsalik, Ephraim L.; Henao, Ricardo; Ginsburg, Geoffrey S.; Reller, Megan E.; Woods, Christopher W. (Oxford University Press, 2020-05-26)
    Background. Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately ...

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