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Browsing Department of Pharmacology by Issue Date

Browsing Department of Pharmacology by Issue Date

Now showing items 1-20 of 31

Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation

Hettihewa, L.M.; Jayasinghe, S.S.; Weerarathna, T.P.; Gunasekara, S.W.; Palangasinghe, S.; Kotapola, I. (OJHAS, 2005-05-10)

We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test ...
Correlation Between Changes of Blood Pressure with Insulin Resistance in type 2 Diabetes Mellitus with 4 weeks of Pioglitazone Therapy

Hettihewa, L.M.; Jayasinghe, S.S.; Imendra, K.G.; Weerarathna, T.P. (Springer, 2008-01)

Objective: To examine effects of pioglitazone (PIO) on systolic, diastolic, pulse and mean blood pressures (SBP, DBP, PP and MP, respectively) in type 2 diabetes mellitus (T2DM). Materials and methods: One hundred and ...
Correlation Between BMI and Insulin Resistance in type 2 Diabetes Mellitus Patients on Pioglitazone Treatment

Hettihewa, L.M.; Dharmasira, L.P.; Ariyaratne, C.D.; Jayasinghe, S.S.; Weerarathna, T.P.; Kotapola, I.G. (Galle Medical Association, 2009-09-25)

doi: 10.4038/gmj.v12i1.1080 Galle Medical Journal Vol.12(1) 2007 18-24
Lipid Abnormalities in type 2 Diabetes Mellitus Patients in Sri Lanka

Hettihewa, L.M.; Gunasekera, S.W.; Jayasinghe, S.S.; Palangasinghe, S.; Weerarathna, T.P.; Kotapola, I. (Galle Medical Association, 2009-09-25)

Background & Objective: Previous studies suggest that the prevalence of dyslipidaemia in type 2 diabetes is high with respect to the general population. But data related to the prevalence of dyslipidaemia in ...
Remission of Diabetes Mellitus after Treatment with Pioglitazone

Jayasinghe, S.S.; Hettihewa, L.M.; Gunasekara, S.W.; Palangasinghe, S.; Imendra, K.G.; Weerarathna, T.P. (Galle Medical Association, 2009-09-28)

Type 2 diabetes is a complex disease that involves insulin secretion abnormalities and defects in the action of insulin on its target tissues. This chronic metabolic disorder is associated with high mortality and ...
Atropine Therapy in acute Anticholinesterase (Organophosphorus/carbamate) Poisoning; adherence to Current Guidelines

Jayasinghe, S.S.; Fernando, A.; Pathirana, K.D.; Gunasinghe, K.K. (Galle Medical Association, 2009-10-08)

Purpose: Atropine is a life saving drug in acute anticholinesterase poisoning. Proper atropinization is associated with better clinical outcome. Hence we aimed to look at the adherence to existing guidelines on atropine ...
Effects of Deliberate Ingestion of Organophosphate or Paraquat on Brain Stem Auditory-Evoked Potentials

Jayasinghe, S.S.; Pathirana, K.D. (Springer, 2011-08-11)

Organophosphate (OP) and paraquat (PQ) ingestion is a serious health problem. A common pathology behind OP or PQ poisoning is the generation of reactive oxygen species (ROS) which is known to cause ototoxicity. The aim of ...
Simple and Sensitive Liquid Chromatography–tandem mass Spectrometry Methods for Quantification of Paraquat in Plasma and Urine: application to experimental and clinical toxicological studies

Wunnapuk, Klintean; Medley, Gregory A.; Liu, Xin; Grice, Jeffrey E.; Jayasinghe, S.S.; Gawarammana, I.; Buckley, Nicholas A.; Roberts, Michael S. (Elsevier, 2011-10-15)

Simple, sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods have been developed and validated for quantification of paraquat (PQ) in plasma and urine. Plasma and urine sample preparation ...
Psychological Distress among Patients with Organophosphorus or Paraquat Poisoning

Jayasinghe, S.S. (Galle Medical Association, 2011-10-30)

Introduction: Recognition of psychological distress following intentional self poisoning is important. The most widely used screening test for psychological distress is the Goldberg's General Health Questionnaire (GHQ). ...
Autonomic Function following Acute Organophosphorus Poisoning: A Cohort Study

Jayasinghe, S.S.; Pathirana, K.D. (Plos One, 2012-05-24)

Autonomic dysfunction after chronic low level exposure to organophosphorus (OP) pesticides has been consistently reported in the literature, but not following a single acute overdose. In order to study autonomic function ...
Adherence to the National Guidelines on the Management of Organophosphorus Poisoning

Jayasinghe, S.S.; Fernando, A.S. (Galle Medical Association, 2012-05-29)

Background: The National Guidelines on the Management of Organophosphorus (OP) poisoning include resuscitation, gastric lavage, administration of atropine and pralidoxime. Atropine should be commenced in the presence of ...
Hearing Impairment in Children Following Bacterial Meningitis; Assessed with Brainstem Auditory Evoked Response (BSAER)

Jayasinghe, S.S.; Pathirana, K.D.; Vimalasena, G.T.H.I.P.; Taranga, D. (Galle Medical Association, 2012-05-29)

Background: Bacterial meningitis is one of the most serious infections occurring in children. Sensorineural hearing loss is the commonest complication of bacterial meningitis. Materials and Methods: We aimed to assess ...
Short Research Communication: Predicting osteopathy among patients with thalassaemia major using selected clinical and biochemical information

Jayasinghe, S.S.; Lekamwasam, S.; De Silva, D.C.L.; Subasinghe, L.; Purasinghe, N. (Galle Medical Association, 2012-11-13)

Objectives: This study assessed the prevalence and surrogate makers of osteopathy among patients with thalassemia major. Methods: Bone mineral densities (BMDs) were measured by dual-energy x-ray absorptiometry of the ...
Effects of Acute Organophosphorus Poisoning on Function of Peripheral Nerves: A Cohort Study

Jayasinghe, S.S.; Pathirana, K.D.; Buckley, Nick A. (Plos One, 2012-11-20)

Background: Following acute organophosphorus (OP) poisoning patients complain of numbness without objective sensory abnormalities or other features of OP induced delayed polyneuropathy. The aim of this study was to measure ...
Slow Repetitive Nerve Stimulation in Patients with Acute Organophosphorus Poisoning after Clinical Recovery

Jayasinghe, S.S.; Pathirana, K.D. (Mashhad University of Medical Sciences, 2013-03-01)

Background: Prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. Neuromuscular junction (NMJ) dysfunction has been shown with repetitive nerve stimulation (RNS). Subclinical NMJ dysfunction ...
Prevalence of Myocardial Ischaemia Among Diabetics determined by Validated Sinhala Version of the WHO Rose Angina Questionnaire

Liyanage, P.L.G.C.; Sathananthan, P.P. (Galle Medical Association, 2013-05-08)

Objectives: The aim of this study was to validate the original version of the Rose Angina Questionnaire (RAQ) and apply it to a group of long standing diabetics in a cross-sectional manner to assess it applicability in ...
Vitamin D: Can we use Higher Doses for Wider Indications?

Liyanage, P.L.G.C.; Weerarathna, T.P. (Galle Medical Association, 2013-10-01)
Adherence to the Current Guidelines in the Management of Paraquat Poisoning

Jayasinghe, S.S.; Fernando, A. (Galle Medical Association, 2013-11-01)

Background: Self-poisoning with paraquat (PQ) is a major health problem with 60 -70% fatality. Fuller’s earth is the mainstay of therapy as other treatment modalities are controversial. Current management guidelines of ...
Arsenic and Human Health Effects: a Review

Chandana, E.P.S.; Jayasumana, C.; De Silva, P.M.C.S.; Abdul, K.S.M.; (Elsevier, 2015-11-01)

Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric air, ground water and food sources are certain. Major sources of arsenic contamination could be either through geological or via ...
Neurotoxic Effects of Paraquat

Jayasinghe, S.S.; Seneviratne, S.A. (Galle Medical Association, 2016-10-15)

Paraquat (1, 1’ - dimethyl - 4, 4 - dipyridyl) is a bipyridyl compound. It was first marketed in 1962 as a broad-spectrum, non-selective and contact herbicide after having been described first byWeidel and Rosso in 1882. ...

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